U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ageusia

MedGen UID:
473585
•Concept ID:
C2364111
•
Sign or Symptom
Synonyms: Loss of Taste; Taste Loss
SNOMED CT: Gustatory anesthesia (36955009); Ageusia (36955009); Loss of taste (36955009); Absence of sense of taste (36955009)
 
HPO: HP:0041051

Definition

A rare condition that is characterized by a complete loss of taste function of the tongue. [from HPO]

Professional guidelines

PubMed

Persons with Co-Existing Neurological Disorders: Risk Analysis, Considerations and Management in COVID-19 Pandemic.
Sharma S, Batra S, Gupta S, Sharma VK, Rahman MH, Kamal MA
CNS Neurol Disord Drug Targets 2022;21(3):228-234. doi: 10.2174/1871527320666210308113457. PMID: 33687889
Post-COVID-19 acute sarcopenia: physiopathology and management.
Piotrowicz K, Gąsowski J, Michel JP, Veronese N
Aging Clin Exp Res 2021 Oct;33(10):2887-2898. Epub 2021 Jul 30 doi: 10.1007/s40520-021-01942-8. PMID: 34328636Free PMC Article
TRP channels in COVID-19 disease: Potential targets for prevention and treatment.
Jaffal SM, Abbas MA
Chem Biol Interact 2021 Aug 25;345:109567. Epub 2021 Jun 22 doi: 10.1016/j.cbi.2021.109567. PMID: 34166652Free PMC Article

Recent clinical studies

Etiology

Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study.
Ballering AV, van Zon SKR, Olde Hartman TC, Rosmalen JGM; Lifelines Corona Research Initiative
Lancet 2022 Aug 6;400(10350):452-461. doi: 10.1016/S0140-6736(22)01214-4. PMID: 35934007Free PMC Article
Long-COVID in children and adolescents: a systematic review and meta-analyses.
Lopez-Leon S, Wegman-Ostrosky T, Ayuzo Del Valle NC, Perelman C, Sepulveda R, Rebolledo PA, Cuapio A, Villapol S
Sci Rep 2022 Jun 23;12(1):9950. doi: 10.1038/s41598-022-13495-5. PMID: 35739136Free PMC Article
Efficacy and safety of gefapixant, a P2X(3) receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials.
McGarvey LP, Birring SS, Morice AH, Dicpinigaitis PV, Pavord ID, Schelfhout J, Nguyen AM, Li Q, Tzontcheva A, Iskold B, Green SA, Rosa C, Muccino DR, Smith JA; COUGH-1 and COUGH-2 Investigators
Lancet 2022 Mar 5;399(10328):909-923. doi: 10.1016/S0140-6736(21)02348-5. PMID: 35248186
COVID-19 in Children: Where do we Stand?
Nikolopoulou GB, Maltezou HC
Arch Med Res 2022 Jan;53(1):1-8. Epub 2021 Jul 6 doi: 10.1016/j.arcmed.2021.07.002. PMID: 34311990Free PMC Article
Multiple Neuroinvasive Pathways in COVID-19.
Bougakov D, Podell K, Goldberg E
Mol Neurobiol 2021 Feb;58(2):564-575. Epub 2020 Sep 29 doi: 10.1007/s12035-020-02152-5. PMID: 32990925Free PMC Article

Diagnosis

Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study.
Ballering AV, van Zon SKR, Olde Hartman TC, Rosmalen JGM; Lifelines Corona Research Initiative
Lancet 2022 Aug 6;400(10350):452-461. doi: 10.1016/S0140-6736(22)01214-4. PMID: 35934007Free PMC Article
Characteristics of viral pneumonia in the COVID-19 era: an update.
Pagliano P, Sellitto C, Conti V, Ascione T, Esposito S
Infection 2021 Aug;49(4):607-616. Epub 2021 Mar 29 doi: 10.1007/s15010-021-01603-y. PMID: 33782861Free PMC Article
Smell and taste disorders in COVID-19: From pathogenesis to clinical features and outcomes.
Mastrangelo A, Bonato M, Cinque P
Neurosci Lett 2021 Mar 23;748:135694. Epub 2021 Feb 15 doi: 10.1016/j.neulet.2021.135694. PMID: 33600902Free PMC Article
Diagnostics for SARS-CoV-2 infections.
Kevadiya BD, Machhi J, Herskovitz J, Oleynikov MD, Blomberg WR, Bajwa N, Soni D, Das S, Hasan M, Patel M, Senan AM, Gorantla S, McMillan J, Edagwa B, Eisenberg R, Gurumurthy CB, Reid SPM, Punyadeera C, Chang L, Gendelman HE
Nat Mater 2021 May;20(5):593-605. Epub 2021 Feb 15 doi: 10.1038/s41563-020-00906-z. PMID: 33589798Free PMC Article
Neurological associations of COVID-19.
Ellul MA, Benjamin L, Singh B, Lant S, Michael BD, Easton A, Kneen R, Defres S, Sejvar J, Solomon T
Lancet Neurol 2020 Sep;19(9):767-783. Epub 2020 Jul 2 doi: 10.1016/S1474-4422(20)30221-0. PMID: 32622375Free PMC Article

Therapy

Anosmia or Ageusia Following COVID-19 Vaccination: A Systematic Review.
Arabzadeh Bahri R, Esmaeilpur Abianeh F, Peisepar M, Hadi R, Basti FA, Maleki S, Radkhah H
Ear Nose Throat J 2024 Jun;103(1_suppl):164S-170S. Epub 2024 Feb 27 doi: 10.1177/01455613241233098. PMID: 38411125
Neuroprotective Agents with Therapeutic Potential for COVID-19.
Zaa CA, Espitia C, Reyes-Barrera KL, An Z, Velasco-Velázquez MA
Biomolecules 2023 Oct 27;13(11) doi: 10.3390/biom13111585. PMID: 38002267Free PMC Article
Long-COVID in children and adolescents: a systematic review and meta-analyses.
Lopez-Leon S, Wegman-Ostrosky T, Ayuzo Del Valle NC, Perelman C, Sepulveda R, Rebolledo PA, Cuapio A, Villapol S
Sci Rep 2022 Jun 23;12(1):9950. doi: 10.1038/s41598-022-13495-5. PMID: 35739136Free PMC Article
Efficacy and safety of gefapixant, a P2X(3) receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials.
McGarvey LP, Birring SS, Morice AH, Dicpinigaitis PV, Pavord ID, Schelfhout J, Nguyen AM, Li Q, Tzontcheva A, Iskold B, Green SA, Rosa C, Muccino DR, Smith JA; COUGH-1 and COUGH-2 Investigators
Lancet 2022 Mar 5;399(10328):909-923. doi: 10.1016/S0140-6736(21)02348-5. PMID: 35248186
Will we ever cure nasal polyps?
Ta NH
Ann R Coll Surg Engl 2019 Jan;101(1):35-39. Epub 2018 Oct 5 doi: 10.1308/rcsann.2018.0149. PMID: 30286644Free PMC Article

Prognosis

COVID-19 in Children: Where do we Stand?
Nikolopoulou GB, Maltezou HC
Arch Med Res 2022 Jan;53(1):1-8. Epub 2021 Jul 6 doi: 10.1016/j.arcmed.2021.07.002. PMID: 34311990Free PMC Article
The Nutrition-COVID-19 Interplay: a Review.
Antwi J, Appiah B, Oluwakuse B, Abu BAZ
Curr Nutr Rep 2021 Dec;10(4):364-374. Epub 2021 Nov 27 doi: 10.1007/s13668-021-00380-2. PMID: 34837637Free PMC Article
Post-COVID-19 acute sarcopenia: physiopathology and management.
Piotrowicz K, Gąsowski J, Michel JP, Veronese N
Aging Clin Exp Res 2021 Oct;33(10):2887-2898. Epub 2021 Jul 30 doi: 10.1007/s40520-021-01942-8. PMID: 34328636Free PMC Article
Smell and taste disorders in COVID-19: From pathogenesis to clinical features and outcomes.
Mastrangelo A, Bonato M, Cinque P
Neurosci Lett 2021 Mar 23;748:135694. Epub 2021 Feb 15 doi: 10.1016/j.neulet.2021.135694. PMID: 33600902Free PMC Article
Neurological manifestations of COVID-19.
Kanwar D, Baig AM, Wasay M
J Pak Med Assoc 2020 May;70(Suppl 3)(5):S101-S103. doi: 10.5455/JPMA.20. PMID: 32515379

Clinical prediction guides

Anosmia or Ageusia Following COVID-19 Vaccination: A Systematic Review.
Arabzadeh Bahri R, Esmaeilpur Abianeh F, Peisepar M, Hadi R, Basti FA, Maleki S, Radkhah H
Ear Nose Throat J 2024 Jun;103(1_suppl):164S-170S. Epub 2024 Feb 27 doi: 10.1177/01455613241233098. PMID: 38411125
Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study.
Ballering AV, van Zon SKR, Olde Hartman TC, Rosmalen JGM; Lifelines Corona Research Initiative
Lancet 2022 Aug 6;400(10350):452-461. doi: 10.1016/S0140-6736(22)01214-4. PMID: 35934007Free PMC Article
Long-COVID in children and adolescents: a systematic review and meta-analyses.
Lopez-Leon S, Wegman-Ostrosky T, Ayuzo Del Valle NC, Perelman C, Sepulveda R, Rebolledo PA, Cuapio A, Villapol S
Sci Rep 2022 Jun 23;12(1):9950. doi: 10.1038/s41598-022-13495-5. PMID: 35739136Free PMC Article
Efficacy and safety of gefapixant, a P2X(3) receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials.
McGarvey LP, Birring SS, Morice AH, Dicpinigaitis PV, Pavord ID, Schelfhout J, Nguyen AM, Li Q, Tzontcheva A, Iskold B, Green SA, Rosa C, Muccino DR, Smith JA; COUGH-1 and COUGH-2 Investigators
Lancet 2022 Mar 5;399(10328):909-923. doi: 10.1016/S0140-6736(21)02348-5. PMID: 35248186
COVID-19 in Children: Where do we Stand?
Nikolopoulou GB, Maltezou HC
Arch Med Res 2022 Jan;53(1):1-8. Epub 2021 Jul 6 doi: 10.1016/j.arcmed.2021.07.002. PMID: 34311990Free PMC Article

Recent systematic reviews

Headaches and facial pain attributed to SARS-CoV-2 infection and vaccination: a systematic review.
Mitsikostas DD, Caronna E, De Tommaso M, Deligianni CI, Ekizoglu E, Bolay H, Göbel CH, Kristoffersen ES, Lampl C, Moro E, Pozo-Rosich P, Sellner J, Terwindt G, Irimia-Sieira P
Eur J Neurol 2024 Jun;31(6):e16251. Epub 2024 Feb 28 doi: 10.1111/ene.16251. PMID: 38415282Free PMC Article
Anosmia or Ageusia Following COVID-19 Vaccination: A Systematic Review.
Arabzadeh Bahri R, Esmaeilpur Abianeh F, Peisepar M, Hadi R, Basti FA, Maleki S, Radkhah H
Ear Nose Throat J 2024 Jun;103(1_suppl):164S-170S. Epub 2024 Feb 27 doi: 10.1177/01455613241233098. PMID: 38411125
Safety and efficacy of P2X3 receptor antagonist for the treatment of refractory or unexplained chronic cough: A systematic review and meta-analysis of 11 randomized controlled trials.
Ramadan A, El-Samahy M, Elrosasy A, Al-Tawil M, Abdelaziz A, Soliman MA, Abouzid M
Pulm Pharmacol Ther 2023 Dec;83:102252. Epub 2023 Sep 9 doi: 10.1016/j.pupt.2023.102252. PMID: 37678663
Long-COVID in children and adolescents: a systematic review and meta-analyses.
Lopez-Leon S, Wegman-Ostrosky T, Ayuzo Del Valle NC, Perelman C, Sepulveda R, Rebolledo PA, Cuapio A, Villapol S
Sci Rep 2022 Jun 23;12(1):9950. doi: 10.1038/s41598-022-13495-5. PMID: 35739136Free PMC Article
Neurological and Head/Eyes/Ears/Nose/Throat Manifestations of COVID-19: A Systematic Review and Meta-Analysis.
Ganesh A, Reis IR, Varma M, Patry DG, Cooke LJ
Can J Neurol Sci 2022 Jul;49(4):514-531. Epub 2021 Jul 21 doi: 10.1017/cjn.2021.180. PMID: 34287109Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...